What condition is typically characterized by an increased number of abnormal cells in breast tissue?

Atypical Ductal Hyperplasia is characterized by the presence of an increased number of abnormal cells within the breast ducts. This condition is often considered a marker for an elevated risk of developing breast cancer, as the abnormal proliferation of cells indicates an atypical growth pattern that can lead to malignancy. Detecting atypical ductal hyperplasia typically involves imaging techniques, such as mammography or ultrasound, and is often confirmed through a biopsy, where the presence of these abnormal cells is confirmed and assessed for potential treatment options.

In contrast, the other conditions listed do not primarily describe an increase in abnormal cells. Calcifications refer to the accumulation of calcium in the breast tissue, which may indicate various benign or malignant processes but does not inherently involve the proliferation of abnormal cells. Paget's Disease is a form of breast cancer that often involves changes in the nipple and surrounding area, but it is not defined by an increased number of abnormal cells in the same way as atypical ductal hyperplasia. Lastly, PASH (Periductal Stromal Hematoma) is a benign condition that manifests as stromal proliferation rather than a significant increase in abnormal cellularity.